干扰素基因刺激蛋白 (STING, TMEM173, MITA) 是一种跨膜接头蛋白，它是细胞病原细胞浆 DNA 的天然免疫应答的一个关键组分 【1,2】。STING 是一种被发现主要在内质网中普遍表达的蛋白 【1】。在细胞浆 DNA 的刺激下，酶 cGAMP 合成酶 (cGAS) 会产生第二信使环-GMP-AMP (cGAMP) 【3,4】。cGAMP 结合并激活 STING 【3,4】。此外，通过 DDX41 和 IFI16 等核酸感应蛋白检测细胞浆 DNA 会导致 STING 激活 【5,6】。激活后，STING 与 TBK1 转位至核周内体，并在 Ser366（小鼠内为 Ser365）位点被 ULK1 磷酸化【7, 8】。TBK1 激酶磷酸化并激活 IRF-3 和 NF-κB，从而诱导 I 型干扰素和其他免疫应答基因 【1,2,7】。

关键词：天然免疫，自身免疫病，肿瘤免疫

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6月新品列表

货号

产品名称

应用

反应性

Adhesion / ECM

86903T

COL5A1 (E6U9W) Rabbit mAb

WB, IP, IHC-Bond, IHC-P, IF-IC

H

94386SF

E-Cadherin (4A2) Mouse mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, M, R

10962S

FAT1 Antibody

WB

H, M, (R)

97174SF

NCAM1 (CD56) (123C3) Mouse mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H

68534S

Occludin (6B8A3) Rat mAb

WB, IF-F, IF-IC

H, M

20302T

Periostin (E5F2S) Rabbit mAb

WB, IP, IHC-P

H

Apoptosis

74860SF

Cleaved Caspase-3 (Asp175) (D3E9) Rabbit mAb (BSA and Azide Free)

IHC-P, IF-IC, F

H, M

95696SF

Cleaved PARP (Asp214) (D64E10) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, Mk

Cell Cycle / Checkpoint Control

62548SF

Ki-67 (8D5) Mouse mAb (BSA and Azide Free)

IHC-P, IF-IC, F

H

60480SF

p21 Waf1/Cip1 (DCS60) Mouse mAb (BSA and Azide Free)

WB, IHC-P

H, Mk

46565SF

p53 (DO-7) Mouse mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H

41359SF

Phospho-Rb (Ser807/811) (D20B12) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, M, R, Mk

Chromatin Regulation / Nuclear Function

52626S

GATAD2B (E2G4R) Rabbit mAb

WB

H, M, R, Mk

73098S

GATAD2B (E4I8Y) Rabbit mAb

WB

H, M, R, Mk

85449S

JMJD7 (E8J8Q) Rabbit mAb

WB

H, R, Mk

87162S

PHF19 (E8P4D) Rabbit mAb

WB, IP, ChIP

H, M, R, Mk

65992S

PSPC1 (E7L8B) Rabbit mAb

WB, IF-IC

H, M, (R)

Cytoskeletal Signaling

62114S

CAPZA1 (E3U1G) Rabbit mAb

WB

H, M, R

10333S

CAPZB (E4H6C) Rabbit mAb

WB

H, M, R

56551S

DOCK5 (E6R9W) Rabbit mAb

WB, IP

H

46251S

Keratin 14 Antibody

WB

H, M, R

69319SF

α-Smooth Muscle Actin (1A4) Mouse mAb (BSA and Azide Free)

WB, IHC-P

H, M, R

Developmental Biology

72528S

Human EGF Recombinant Protein

-

-

87548S

Mouse FGF-basic/FGF2 Recombinant Protein

-

-

87179T

HIF-2α (E7K6E) Rabbit mAb

WB, ChIP

H

60770T

MITF (D5) Mouse mAb

IHC-P, IF-IC

H

42028S

Human PDGF-AA Recombinant Protein

-

-

25330S

RUNX3/AML2 (D6E2) Rabbit mAb (Alexa Fluor® 488 Conjugate)

F

H, M, R

81849S

RUNX3/AML2 (D6E2) Rabbit mAb (Alexa Fluor® 647 Conjugate)

F

H, M, R

50850S

TWIST1 (E2M5V) Rabbit mAb

IHC-P

M

Glucose / Energy Metabolism

0

40941S

IGF-II (E3F3N) Rabbit mAb

WB

H, M, R

Immunology and Inflammation

47359SF

CD3ε (D4V8L) Rabbit mAb (BSA and Azide Free)

WB, IHC-Bond, IHC-P

M

32814S

CD7 (E4G1Q) XP® Rabbit mAb

WB, IHC-Bond, IHC-P

H

32814T

CD7 (E4G1Q) XP® Rabbit mAb

WB, IHC-Bond, IHC-P

H

53986C

PathScan® Phospho-CrkL (Tyr207) Sandwich ELISA Kit

ELISA

H

49392S

DOCK2 (E7X1P) Rabbit mAb

WB, IP

H

87015S

Human GM-CSF Recombinant Protein

-

-

87791SF

Granzyme B (E5V2L) Rabbit mAb (Mouse Specific) (BSA and Azide Free)

WB, IHC-Bond, IHC-P, F

M

29881S

GUCY2C (E1Q6S) Rabbit mAb

WB, IP, IF-IC

H

37517S

GUCY2C (E6I2U) Rabbit mAb

WB, IP, IHC-P

H

50384S

IgA (N1CLA) Mouse mAb

IHC-Bond, IHC-P

H

33469S

IgG (RWP49) Mouse mAb

IHC-Bond, IHC-P

H

54059S

Human IL-1β Recombinant Protein

-

-

95742SF

IL-2Rα/CD25 (E9W2J) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-Bond, IHC-P, IF-F, F

M

98018S

Mouse IL-3 Recombinant Protein

-

-

64063S

Mouse IL-7 Recombinant Protein

-

-

79627S

Human IL-13 Recombinant Protein

-

-

84087S

Human β-NGF Recombinant Protein

-

-

74906S

OAS3 (E4X7Z) Rabbit mAb

WB

H

60847SF

PD-1 (EH33) Mouse mAb (IHC-Specific) (BSA and Azide Free)

IHC-Bond, IHC-P

H

39356SF

PD-L1 (405.9A11) Mouse mAb (BSA and Azide Free)

WB, IHC-P

H

24224SF

PD-L1 (Extracellular Domain Specific) (E1J2J™) Rabbit mAb (BSA and Azide Free)

WB, IHC-P

H

37908S

SERPINB9 (E9J8J) XP® Rabbit mAb

WB, IHC-P

H

37908T

SERPINB9 (E9J8J) XP® Rabbit mAb

WB, IHC-P

H

58551S

SERPINB9 (E9X9Z) Rabbit mAb

WB, F

H

88845SF

Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, M

73533SF

Phospho-Stat3 (Tyr705) (D3A7) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-Bond, IHC-P, IF-IC, F

H, M, R, Mk

51879SF

Phospho-Stat5 (Tyr694) (C11C5) Rabbit mAb (BSA and Azide Free)

WB, IHC-P, F

H, M

90947S

STING (E9X7F) Rabbit mAb

IF-F, IF-IC, F

H, M

16769S

Human TNF-α Recombinant Protein

-

-

24095S

Mouse TNF-α Recombinant Protein

-

-

87804S

Tox3 Antibody

WB

H

Infectious Diseases

19595S

SARS-CoV-2 2'-O-ribose Methyltransferase (E6N2C) Rabbit mAb

WB

Vir

93220S

SARS-CoV-2 3C-Like Protease (E9A1K) Rabbit mAb

WB

Vir

MAP Kinase Signaling

77955SF

Phospho-c-Jun (Ser73) (D47G9) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-F, IF-IC, F

H, M, R, Mk, Pg

62979SF

Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, M, R, Mk, Mi, Pg, Sc

45899SF

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC, F

H, M, R, Hm, Mk, Mi, Dm, Z, B, Dg, Pg, Sc

55773SF

Phospho-p90RSK (Thr359) (D1E9) Rabbit mAb (BSA and Azide Free)

WB, IHC-P, IF-IC

H, Mk

58328SF

Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb (BSA and Azide Free)